AS160 (phospho-Ser588) rabbit pAb
Product Sizes
50UL
£ POA
ES18240-50UL
100UL
£ POA
ES18240-100UL
About this Product
- SKU:
- ES18240
- Additional Names:
- TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein; and contains two phopshotyrosine-binding domains (PTB1 and PTB2); a calmodulin-binding domain (CBD); a Rab-GTPase domain; and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4); important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane; suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin; this protein is phosphorylated; dissociates from GLUT4 vesicles; resulting in increased GLUT4 at the cell surface; and enhanced glucose transport. Ph
- Immunogen:
- Synthesized phosho peptide around human AS160 (Ser588)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
