BCSC-1 rabbit pAb
Product Sizes
50UL
£ POA
ES1766-50UL
100UL
£ POA
ES1766-100UL
About this Product
- SKU:
- ES1766
- Additional Names:
- VWA5A; BCSC1; LOH11CR2A; von Willebrand factor A domain-containing protein 5A; Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- VWA5A (von Willebrand factor A domain containing 5A); also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein); is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues; with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene; deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors; and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin; alpha-catenin; and p53; resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms; the gene encoding VWA5A maps to human chromosome 11q24.2.
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
