CXXC4 rabbit pAb
Product Sizes
50UL
£ POA
ES17165-50UL
100UL
£ POA
ES17165-100UL
About this Product
- SKU:
- ES17165
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled; a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition; the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides; localize to promoters and CpG islands; and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2; an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans; a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq; Sep 2015];
- Immunogen:
- Synthesized peptide derived from human CXXC4 AA range: 15-65
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
