DAB2 rabbit pAb
Product Sizes
50UL
£ POA
ES17027-50UL
100UL
£ POA
ES17027-100UL
About this Product
- SKU:
- ES17027
- Additional Names:
- Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells; but is down-regulated or absent from ovarian carcinoma cell lines; suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2; an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras); via its C-terminal proline-rich sequences; and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq; Oct 2011];
- Immunogen:
- Synthesized peptide derived from human DAB2 AA range: 683-733
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
