GPX4 rabbit pAb
Product Sizes
50UL
£ POA
ES15919-50UL
100UL
£ POA
ES15919-100UL
About this Product
- SKU:
- ES15919
- Additional Names:
- Phospholipid hydroperoxide glutathione peroxidase; mitochondrial (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene belongs to the glutathione peroxidase family; members of which catalyze the reduction of hydrogen peroxide; organic hydroperoxides and lipid hydroperoxides; and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates; which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus; it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase; as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein; containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon; which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure; designated the Sec insertion sequence (SECIS) element; that is necessary for the recognition of UGA as a Sec codon; rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq; Oct 2016];
- Immunogen:
- Synthesized peptide derived from human GPX4 AA range: 84-134
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
