AChRα10 rabbit pAb
Product Sizes
50UL
£ POA
ES1581-50UL
100UL
£ POA
ES1581-100UL
About this Product
- SKU:
- ES1581
- Additional Names:
- CHRNA10; NACHRA10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium; the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear; this may lead to a reduction in basilar membrane motion; altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.;miscellaneous:The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile; binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).;similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.;subunit:Forms hetero-oligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.;tissue specificity:Expressed in inner-ear tissue; tonsil; immortalized B-cells; cultured T-cells and peripheral blood lymphocytes.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CHRNA10. AA range:394-443
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
