HER2 (Phospho-Tyr1139) rabbit pAb
Product Sizes
50UL
£ POA
ES15789-50UL
100UL
£ POA
ES15789-100UL
About this Product
- SKU:
- ES15789
- Additional Names:
- Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD antigen CD340)
- Application:
- Immunohistochemistry, Immunofluorescence, Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However; it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer; stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways; such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported; with the most common allele; Ile654/Ile655; shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers; including breast and ovarian tumors. Alternative splicing results in several additional transcript variants; some encoding d
- Immunogen:
- Synthesized peptide derived from human HER2 (Phospho-Tyr1139)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
