IMPA1 rabbit pAb
Product Sizes
50UL
£ POA
ES15467-50UL
100UL
£ POA
ES15467-100UL
About this Product
- SKU:
- ES15467
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol; a precursor of phosphatidylinositol; and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1;4;5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1;3-diphosphate; myo-inositol-1;4-diphosphate; scyllo-inositol-phosphate; glucose-1-phosphate; glucose-6-phosphate; fructose-1-phosphate; beta-glycerophosphate; and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq; Dec 2014];
- Immunogen:
- Synthesized peptide derived from human IMPA1 AA range: 158-208
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
