MBD2 rabbit pAb
Product Sizes
50UL
£ POA
ES15022-50UL
100UL
£ POA
ES15022-100UL
About this Product
- SKU:
- ES15022
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2; MBD1; MBD2; MBD3; and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins; with the exception of MBD3; is capable of binding specifically to methylated DNA. MECP2; MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription; as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq; Feb 2011];
- Immunogen:
- Synthesized peptide derived from human MBD2 AA range: 110-160
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
