Ksr-1 (phospho Ser392) rabbit pAb
Product Sizes
50UL
£ POA
ES1473-50UL
100UL
£ POA
ES1473-100UL
About this Product
- SKU:
- ES1473
- Additional Names:
- KSR1; KSR; Kinase suppressor of Ras 1
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.;function:Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself; it has no demonstrated kinase activity.;PTM:Phosphorylated on Ser-309 and; to a higher extent; on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells; phosphorylated KSR1 is cytoplasmic and in stimulated cells; dephosphorylated KSR1 is membrane-associated.;similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.;similarity:Contains 1 phorbol-ester/DAG-type zinc finger.;similarity:Contains 1 protein kinase domain.;subcellular location:In unstimulated cells; where the phosphorylated form is bound to a 14-3-3 protein; sequestration in the cytoplasm occurs. Following growth factor treatment; the protein is free for membrane translocation; and it moves from the cytoplasm to the cell periphery.;subunit:Interacts with HSPCA/HSP90; YWHAB/14-3-3; CDC37; MAP2K/MEK; MARK3; PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK; in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human KSR around the phosphorylation site of Ser392. AA range:358-407
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
