NISCH rabbit pAb
Product Sizes
50UL
£ POA
ES14488-50UL
100UL
£ POA
ES14488-100UL
About this Product
- SKU:
- ES14488
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans; this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue; this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq; Jan 2013];
- Immunogen:
- Synthesized peptide derived from human NISCH AA range: 234-284
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
