PEN2 rabbit pAb
Product Sizes
50UL
£ POA
ES14162-50UL
100UL
£ POA
ES14162-100UL
About this Product
- SKU:
- ES14162
- Application:
- Immunohistochemistry, Immunofluorescence
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Presenilins; which are components of the gamma-secretase protein complex; are required for intramembranous processing of some type I transmembrane proteins; such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides; the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling; and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq; Jul 2013];
- Immunogen:
- Synthesized peptide derived from human PEN2 AA range: 51-101
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
