PSME1 rabbit pAb
Product Sizes
50UL
£ POA
ES13879-50UL
100UL
£ POA
ES13879-100UL
About this Product
- SKU:
- ES13879
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes; a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base; which contains 6 ATPase subunits and 2 non-ATPase subunits; and a lid; which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome; the immunoproteasome; is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator; referred to as the 11S regulator or PA28; that replaces the 19S regulator. Three subunits (alpha; beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator; one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq; Jul 2013];
- Immunogen:
- Synthesized peptide derived from human PSME1 AA range: 60-110
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
