DTL rabbit pAb
Product Sizes
50UL
£ POA
ES11892-50UL
100UL
£ POA
ES11892-100UL
About this Product
- SKU:
- ES11892
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- developmental stage:Expressed in all fetal tissues examined; included brain; lung; liver; and kidney.;function:Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. Seems to be necessary to ensure proper cell cycle regulation of DNA replication. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. May play a role in cell proliferation of NT2 embryonal carcinoma cells.;PTM:Phosphorylated upon DNA damage; probably by ATM or ATR.;similarity:Belongs to the WD repeat cdt2 family.;similarity:Contains 7 WD repeats.;subcellular location:Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.;subunit:Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1.;tissue specificity:Expressed in placenta and testis; very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined; with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node; and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
