SACS rabbit pAb
Product Sizes
50UL
£ POA
ES11443-50UL
100UL
£ POA
ES11443-100UL
About this Product
- SKU:
- ES11443
- Application:
- Immunohistochemistry, Immunofluorescence
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes the sacsin protein; which includes a UbL domain at the N-terminus; a DnaJ domain; and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system; also found in skin; skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS); a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al.; PubMed: 19208651).
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 4291-4340
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
