SARM1 rabbit pAb
Product Sizes
50UL
£ POA
ES11434-50UL
100UL
£ POA
ES11434-100UL
About this Product
- SKU:
- ES11434
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- caution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.;function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction; without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.;similarity:Contains 1 TIR domain.;similarity:Contains 2 SAM (sterile alpha motif) domains.;subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.;tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 281-330
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
