LST8 rabbit pAb
Product Sizes
50UL
£ POA
ES11340-50UL
100UL
£ POA
ES11340-100UL
About this Product
- SKU:
- ES11340
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Unessential component of the TORC1 complex and essential component of the TORC2 complex. TORC1 controls cell growth in response to environmental signals; and is inactivated by nutrient limitation and environmental stress. Within TORC1; LST8 interacts directly with FRAP1 and enhances its kinase activity. In nutrient-poor conditions; stabilizes the FRAP1-RAPTOR interaction and favors RAPTOR-mediated inhibition of FRAP1 activity. TORC2 controls polarity of the actin cytoskeleton via the RAC1 pathway. TORC2 mediates phosphorylation of Akt/PKB on 'Ser-473' and phosphorylation of PKCalpha on 'Ser-657'.;similarity:Belongs to the WD repeat LST8 family.;similarity:Contains 7 WD repeats.;subunit:Interacts with FRAP1; RAPTOR and RHEB. Part of the target of rapamycin complex 1 (TORC1) which contains LST8; FRAP1; RAPTOR and AKT1S1. TORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the target of rapamycin complex 2 (TORC2) which contains FRAP1; LST8; PROTOR1; RICTOR and MAPKAP1. Contrary to TORC1; TORC2 does not bind to and is not sensitive to FKBP12-rapamycin.;tissue specificity:Broadly expressed; with highest levels in skeletal muscle; heart and kidney.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 100-180
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
