SIGIR rabbit pAb
Product Sizes
50UL
£ POA
ES10876-50UL
100UL
£ POA
ES10876-100UL
About this Product
- SKU:
- ES10876
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor; probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.;similarity:Belongs to the interleukin-1 receptor family.;similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.;similarity:Contains 1 TIR domain.;subunit:Interacts with IL1R1; IRAK1; TLR4; TLR5; TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1; SIGIRR; MYD88; IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4; SIG1IR; MYD88; IRAK1 and TRAF6.;tissue specificity:Mainly expressed in epithelial tissues such as kidney; lung and gut.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
