MIB2 rabbit pAb
Product Sizes
50UL
£ POA
ES10756-50UL
100UL
£ POA
ES10756-100UL
About this Product
- SKU:
- ES10756
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors; which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta; leading to endocytosis of Delta receptors.;induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent; 5'-aza-2-deoxycytidine; restores expression; suggesting that down-regulation is the result of methylation of the gene.;pathway:Protein modification; protein ubiquitination.;PTM:Ubiquitinated. Possibly via autoubiquitination.;similarity:Contains 1 ZZ-type zinc finger.;similarity:Contains 2 MIB/HERC2 domains.;similarity:Contains 2 RING-type zinc fingers.;similarity:Contains 9 ANK repeats.;subcellular location:Colocalizes with endosomal compartments.;subunit:Interacts with actin monomer.;tissue specificity:Expressed in skeletal muscle; and to a lesser extent in heart; brain and kidney.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
