KBRS2 rabbit pAb
Product Sizes
50UL
£ POA
ES10753-50UL
100UL
£ POA
ES10753-100UL
About this Product
- SKU:
- ES10753
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:In contrast to other members of the Ras family; the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65; which are replaced by Ala and Leu residues; respectively; and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.;function:Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals; explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.;sequence caution:Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.;similarity:Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.;subunit:Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However; it probably only interacts with NFKBIB in vivo.;tissue specificity:Widely expressed.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
