SRRM1 rabbit pAb
Product Sizes
50UL
£ POA
ES10607-50UL
100UL
£ POA
ES10607-100UL
About this Product
- SKU:
- ES10607
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins; SFRS4; SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.;similarity:Belongs to the splicing factor SR family.;similarity:Contains 1 PWI domain.;subunit:Identified in the spliceosome C complex; at least composed of AQR; ASCC3L1; C19orf29; CDC40; CDC5L; CRNKL1; DDX23; DDX41; DDX48; DDX5; DGCR14; DHX35; DHX38; DHX8; EFTUD2; FRG1; GPATC1; HNRPA1; HNRPA2B1; HNRPA3; HNRPC; HNRPF; HNRPH1; HNRPK; HNRPM; HNRPR; HNRPU; KIAA1160; KIAA1604; LSM2; LSM3; MAGOH; MORG1; PABPC1; PLRG1; PNN; PPIE; PPIL1; PPIL3; PPWD1; PRPF19; PRPF4B; PRPF6; PRPF8; RALY; RBM22; RBM8A; RBMX; SART1; SF3A1; SF3A2; SF3A3; SF3B1; SF3B2; SF3B3; SFRS1; SKIV2L2; SNRPA1; SNRPB; SNRPB2; SNRPD1; SNRPD2; SNRPD3; SNRPE; SNRPF; SNRPG; SNW1; SRRM1; SRRM2; SYF2; SYNCRIP; TFIP11; THOC4; U2AF1; WDR57; XAB2 and ZCCHC8. Found in a pre-mRNA splicing complex with SFRS4; SFRS5; SNRP70; SNRPA1; SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70; SNRPA1; SRRM1 and TRA2B/SFRS10. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK; PRPF8; NCBP1; RBM8A; RNPS1; SRRM1 and THOC4. Interacts with BAT1; CPSF1; RBM8A; RNPS1; and THOC4. Seems to be a compound of RNA export complexes that are released from speckles in a ATP-dependent manner.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
