Cleaved-Factor XII HC (R372) rabbit pAb
Product Sizes
50UL
£ POA
ES1060-50UL
100UL
£ POA
ES1060-100UL
About this Product
- SKU:
- ES1060
- Additional Names:
- F12; Coagulation factor XII; Hageman factor; HAF
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains; two epidermal growth factor (EGF)-like domains; a kringle domain and a proline-rich domain; whereas the light chain contains only a catalytic domain. On activation; further cleavages takes place in the heavy chain; resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein; which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation; fibrinolysis; and the generation of bradykinin and angiotensin. It activat
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FA12. AA range:323-372
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
