MRCKG rabbit pAb
Product Sizes
50UL
£ POA
ES10590-50UL
100UL
£ POA
ES10590-100UL
About this Product
- SKU:
- ES10590
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;cofactor:Magnesium.;enzyme regulation:Maintained in an inactive; closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this; releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation.;function:May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion; through the regulation of MYPT1 and thus MLC2 phosphorylation.;similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.;similarity:Contains 1 AGC-kinase C-terminal domain.;similarity:Contains 1 CNH domain.;similarity:Contains 1 CRIB domain.;similarity:Contains 1 PH domain.;similarity:Contains 1 phorbol-ester/DAG-type zinc finger.;similarity:Contains 1 protein kinase domain.;subcellular location:Concentrates at the leading edge of cells.;subunit:Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42.;tissue specificity:Expressed in heart and skeletal muscle.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 1370-1450
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
