NLK rabbit pAb
Product Sizes
50UL
£ POA
ES10199-50UL
100UL
£ POA
ES10199-100UL
About this Product
- SKU:
- ES10199
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;cofactor:Magnesium.;enzyme regulation:Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin.;function:Role in cell fate determination; required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator; CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction; acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.;PTM:Dually phosphorylated on Thr-291 and Tyr-293; which activates the enzyme.;similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.;similarity:Contains 1 protein kinase domain.;subcellular location:Predominantly nuclear. A smaller fraction is cytoplasmic.;subunit:Interacts with STAT3 (By similarity). Interacts with RNF138/NARF and TCF7L2/TCF4. Interacts with HIPK2 and MYB.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 230-310
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
