PLXB1 rabbit pAb
Product Sizes
50UL
£ POA
ES10014-50UL
100UL
£ POA
ES10014-100UL
About this Product
- SKU:
- ES10014
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- disease:Overexpressed and constitutively tyrosine phosphorylated in colon; liver; pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth.;function:Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance; invasive growth and cell migration.;PTM:Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.;PTM:Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.;similarity:Belongs to the plexin family.;similarity:Contains 1 Sema domain.;similarity:Contains 3 IPT/TIG domains.;subunit:Monomer; and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Binds ARHGEF11; ARHGEF12; ERBB2; MET; MST1R; RND1; NRP1 and NRP2.;tissue specificity:Highly expressed in fetal kidney; and at slightly lower levels in fetal brain; lung and liver.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 90-170
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
