Recombinant Human B7-H3 (C-6His)
Product Sizes
50ug
£ POA
EPT290-50UG
About this Product
- SKU:
- EPT290
- Additional Names:
- CD276; B7H34Ig-B7-H3; B7-H3; B7 homolog 3; CD276 antigen; CD276 molecule; Costimulatory molecule
- Extra Details:
- CD276; also known as B7-H3; is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes; and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions; providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells; natural killer cells; and antigen presenting cells; as well as some non-immune cells; such as osteoblasts; fibroblasts; fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients; suggesting that it may play a role in tumor cell migration.
- Molecular Weight:
- 47.3 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
