Recombinant Mouse CD47 (C-6His)
Product Sizes
50ug
£ POA
EPT216-50UG
About this Product
- SKU:
- EPT216
- Additional Names:
- Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6
- Extra Details:
- CD47; also known as Integrin‑Associated Protein (IAP) and OA3; is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain; five membrane-spanning regions with short intervening loops; and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets; and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA; it binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cellcell adhesion; it enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. It may play a role in membrane transport and/or integrin dependent signal transduction. It also prevents premature elimination of red blood cells.
- Molecular Weight:
- 16.7 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
