Recombinant Mouse CCL2
Product Sizes
10ug
£ POA
EPT150-10UG
About this Product
- SKU:
- EPT150
- Additional Names:
- C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1;Platelet-derived growth factor-inducible protein JE; Small-inducible cytokine A2; Ccl2; Je; Mcp1; Scya2
- Extra Details:
- C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence; and 58%; 56%; 55%; 53% and 53% aa identity with human; equine; porcine; bovine and canine CCL2; respectively. Fibroblasts; glioma cells; smooth muscle cells; endothelial cells; lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation; but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity; CCL2 induces enzyme and cytokine release by monocytes; NK cells and lymphocytes; and histamine release by basophils that express its receptor; CCR2. Additionally; it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis; multiple sclerosis and allergic asthma.
- Molecular Weight:
- 8.5 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Supplier:
- ELK Biotechnology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
