Recombinant Mouse FGFb
Product Sizes
50ug
£ POA
EPT120-50UG
About this Product
- SKU:
- EPT120
- Additional Names:
- Fibroblast Growth Factor 2; FGF-2; Basic Fibroblast Growth Factor; bFGF; Heparin-Binding Growth Factor 2; HBGF-2; Fgf2; Fgf-2
- Extra Details:
- FGF basic is one of 22 mitogenic proteins of the FGF family; which show 35-60% amino acid conservation. Unlike other FGFs; FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat; and 95% identity with human; bovine; and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding; dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins; polysaccharides and lipids with lower affinity. Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype; suggesting compensation by other FGF family members. FGF basic modulates such normal processes as angiogenesis; wound healing and tissue repair; embryonic development and differentiation; neuronal function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis is reminiscent of a variety of pathological conditions.
- Molecular Weight:
- 17.15 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Supplier:
- ELK Biotechnology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
