Recombinant 2019-nCoV Papain-Like Protease
Product Sizes
50ug
£ POA
EPT114-50UG
About this Product
- SKU:
- EPT114
- Additional Names:
- Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
- Extra Details:
- Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases; a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional; mature subunits; specifically; PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation; PLPro possesses a deubiquitinating and deISGylating activity. In vivo; this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
- Molecular Weight:
- 35.8 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at ≤-70[o]C; stable for 6 months after receipt. Store at ≤-70[o]C; stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
- Supplier:
- ELK Biotechnology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
