Recombinant Human HGF (C-6His)
Product Sizes
50ug
£ POA
EPT082-50UG
About this Product
- SKU:
- EPT082
- Additional Names:
- Hepatocyte growth factor; HPTA; HGF; SF; Scatter factor; Hepatopoietin-A
- Extra Details:
- HGF; is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains; 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase; HGF R/c-MET. HGF regulates epithelial morphogenesis by inducing cell scattering and branching tubulogenesis. It can also alter epithelium morphology by the induction of nectin-1 alpha ectodomain shedding; an adhesion protein component of adherens junctions. HGF regulates cell growth; cell motility; and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto oncogenic c-Met receptor. HGF is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis; cell motility; and matrix invasion gives it a central role in angiogenesis; tumorogenesis; and tissue regeneration.
- Molecular Weight:
- 26&53.7 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Supplier:
- ELK Biotechnology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
