Recombinant 2019-nCoV Helicase (N-6His-MBP)
Product Sizes
50ug
£ POA
EPT080-50UG
About this Product
- SKU:
- EPT080
- Additional Names:
- SARS-CoV 2 Helicase; SARS-CoV 2 nsp13
- Extra Details:
- The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity; using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction; and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially; helicases were only thought to be molecular engines that unwind nucleic acids during replication; recombination; and DNA repair. Recent studies have shown that they are also involved in other biological processes; including displacement of proteins from nucleic acid; movement of Holliday junctions; chromatin remodeling; catalysis of nucleic acid conformational changes; several aspects of RNA metabolism; including transcription; mRNA splicing; mRNA export; translation; RNA stability and mitochondrial gene expression. Some human diseases; including Bloom’s syndrome; Werner’s syndrome; and Xeroderma Pigmentosum have been associated with defects in helicase function.
- Molecular Weight:
- 112.8 KDa
- Purity:
- Greater than 80% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at ≤-70[o]C; stable for 6 months after receipt. Store at ≤-70[o]C; stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
- Supplier:
- ELK Biotechnology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
