Recombinant Human CD207 (N-6His)
Product Sizes
50ug
£ POA
EPT060-50UG
About this Product
- SKU:
- EPT060
- Additional Names:
- CD207 antigen; langerin; CD207; C-type lectin domain family 4 member K
- Extra Details:
- Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain; a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%; 62%; 71% aa identity with mouse; rat and bovine langerin ECD; respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose; N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.
- Molecular Weight:
- 31.5 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Supplier:
- ELK Biotechnology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
