PDGFRα (5D1) Mouse mAb
Product Sizes
50UL
£ POA
EM1336-50UL
100UL
£ POA
EM1336-100UL
About this Product
- SKU:
- EM1336
- Application:
- Immunohistochemistry
- Clonality:
- Monoclonal
- Concentration:
- 1mg/mL
- Extra Details:
- Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded; dimeric isoforms (PDGF AA; PDGF AB; PDGF BB; PDGF CC; and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases; PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). PDGFRα and PDGFRβ can each form heterodimers with EGFR; which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition; which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation; followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules; such as GRB2; Src; GAP; PI3 kinase; PLCγ; and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth; actin reorganization; migration; and differentiation.
- Immunogen:
- Synthetic Peptide
- Isotype:
- IgG1
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Mouse
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Monoclonal Antibody
