CD10 Mouse mAb
Product Sizes
50UL
£ POA
EM1072-50UL
100UL
£ POA
EM1072-100UL
About this Product
- SKU:
- EM1072
- Additional Names:
- Atriopeptidase; CALLA; Enkephalinase; EPN; membrane metallo endopeptidase; MME; NEP; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11
- Application:
- Immunohistochemistry
- Clonality:
- Monoclonal
- Concentration:
- 1mg/mL
- Extra Details:
- CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides; most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein; the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons; neprilysin is regulated by the protein nicastrin; a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid betaThe distinct peripheral cytosolic proteins; alpha; beta and gamma catenin (102; 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
- Immunogen:
- Synthetic Peptide
- Isotype:
- IgG1
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Mouse
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Monoclonal Antibody
