COX1/Cyclooxygenase 1 Rabbit pAb
Product Sizes
50UL
£ POA
EA023-50UL
100UL
£ POA
EA023-100UL
About this Product
- SKU:
- EA023
- Application:
- Western Blot, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1mg/mL
- Extra Details:
- Cyclooxygenase-1 (COX-1); also known as prostaglandin G/H synthase 1; prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1; is an enzyme that in humans is encoded by the PTGS1 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2; which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs; but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered; but their precise roles are yet to be describedGalectin 3 is one of the more extensively studied members of this family and is a 30 kDa protein. Due to a C-terminal carbohydrate binding site; Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. Galectin 3 is normally distributed in epithelia of many organs; in various inflammatory cells; including macrophages; as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation; cell proliferation; cell differentiation and through trans-activation by viral proteins.
- Immunogen:
- Synthetic Peptide
- Isotype:
- IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
