Mini Sample Mouse IL-18 (Interleukin 18) ELISA Kit
Product Sizes
24 tests
£143.00
E-MSEL-M0111-24TESTS
48 tests
£302.00
E-MSEL-M0111-48TESTS
96 tests
£365.00
E-MSEL-M0111-96TESTS
About this Product
- SKU:
- E-MSEL-M0111
- Additional Names:
- IL18,IGIF,IL-1g,IL-1F4,Interferon-gamma-inducing factor
- Application:
- ELISA
- Extra Details:
- Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1 gamma, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-gamma and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-gamma that inhibits IgE production.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Range:
- 15.63-1000 pg/mL
- Reactivities:
- Mouse
- Sensitivity:
- 9.38 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:p-mini_sample_mouse_il_18_(interleukin_18)_elisa_kit-e_msel_m0111
