Human IL-37 Antibody Pair Set
Product Sizes
1 set
£882.00
E-KAB-0719-1SET
About this Product
- SKU:
- E-KAB-0719
- Additional Names:
- IL37,FIL1,FIL1(ZETA),FIL1Z,IL-1F7,IL-1H,IL-1H4,IL-1RP1,IL-37,IL1F7,IL1H4,IL1RP1
- Application:
- ELISA
- Buffer:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Extra Details:
- IL-37,also known as IL-1F7,belongs to the IL-1 family. There are five isoforms generated by alternative splicing,identified as IL-37a-e. IL-37b is the largest isoform and IL-37a contains a unique N-terminal sequences,absent in other isoforms. IL-37 is exclusively expressed only in human cells,but not found in murine cells. IL-37 isoforms are expressed in a tissue-specific manner. Its expression is upregulated upon LPS stimulation as well as TLR agonists in human blood monocytes and macrophages,whereas it is downregulated by IL-12,IL-32 and combination of GM-CSF and IL-4. IL-37 has been shown to translocate to the nucleus upon LPS treatment. IL-37 is a broad anti-inflammatory cytokine. IL-37a and IL-37b inhibits LPS-treated pro-inflammatory cytokine production in M1-differentiated macrophages and dendritic cells via IL-18RA Alpha and SIGIRR/IL-1R8.
- Format:
- Colorimetric method;ELISA;Sandwich
- Formulation:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Immunogen:
- IL-37
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Antibody Pair
- Manufacturer's Data Sheet:p-human_il_37_antibody_pair_set-e_kab_0719
