Mouse PDGF-BB Antibody Pair Set
Product Sizes
1 set
£882.00
E-KAB-0684-1SET
About this Product
- SKU:
- E-KAB-0684
- Additional Names:
- c-sis,IBGC5,PDGF2,PDGF-2,PDGFB,Platelet-derived growth factor subunit B,SIS,SSV,PDGFBB,PDGF-BB
- Application:
- ELISA
- Buffer:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Extra Details:
- PDGF-BB is a mitogen that was initially identified as simian sarcoma viral oncogene homolog. It belongs to the Platelet-Derived Growth Factor (PDGF) family which includes five members: PDGF-AA,PDGF-BB,PDGF-AB,PDGF-CC,and PDGF-DD. PDGF-AA,AB,and BB dimers are processed intracellularly and secreted as active dimers that readily activate PDGF receptors (PDGFRs). PDGF-BB exerts its biological functions through the activation of dimeric receptors that are made up of two structurally similar protein-tyrosine kinase receptor subunits (A AlphaA Alpha-,A AlphaB Beta-,or B BetaB Beta-PDGFR). PDGF-BB induces VSMC dedifferentiation by the down regulation of contractile protein markers and the up regulation of MMP-2. In cutaneous remodeling,studies ex vivo revealed that PDGF-BB is a mitogen and chemoattractant for dermal fibroblasts. Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases,especially malignancy. Autocrine signaling is a consequence of PDGF-BB overexpression,which is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP).
- Format:
- Colorimetric method;ELISA;Sandwich
- Formulation:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Immunogen:
- PDGF-BB
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Antibody Pair
- Manufacturer's Data Sheet:p-mouse_pdgf_bb_antibody_pair_set-e_kab_0684
