Human ErbB3 Antibody Pair Set
Product Sizes
1 set
£882.00
E-KAB-0424-1SET
About this Product
- SKU:
- E-KAB-0424
- Additional Names:
- Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3,HER3
- Application:
- ELISA
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Extra Details:
- This gene encodes a member of the epidermal growth factor receptor ( EGFR ) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However , it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers , including prostate , bladder , and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported , but they have not been thoroughly characterized.
- Format:
- Colorimetric method;ELISA;Sandwich
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- ErbB3
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Antibody Pair
- Manufacturer's Data Sheet:p-human_erbb3_antibody_pair_set-e_kab_0424
