Mouse TFPI (Tissue Factor Pathway Inhibitor) ELISA Kit
Product Sizes
24 tests
£134.00
E-EL-M3132-24TESTS
48 tests
£355.00
E-EL-M3132-48TESTS
96 tests
£431.00
E-EL-M3132-96TESTS
About this Product
- SKU:
- E-EL-M3132
- Additional Names:
- Tfpi,EPI,LACI,lipoprotein-associated coagulation
- Application:
- ELISA
- Extra Details:
- Tissue Factor Pathway Inhibitor (TFPI), also called extrinsic pathway inhibitor (EPI) and lipoprotein-associated coagulation inhibitor (LACI), is a key Kunitz-type serine protease inhibitor regulating the extrinsic blood coagulation pathway. It directly inhibits factor X (Xa) and, in an Xa-dependent way, inhibits VIIa/tissue factor (TF) activity by forming a quaternary Xa/LACI/VIIa/TF complex, playing a vital antithrombotic role.TFPI is mainly produced by vascular endothelial cells, it is also expressed by vascular smooth muscle cells, megakaryocytes/platelets, monocytes and other cells, and detected in macrophages and T cells in atherosclerotic lesions. Its structure has three tandem Kunitz domains (K1, K2, K3) and a basic C-terminal region: K2 inhibits FXa's active site, while K1 inhibits FVIIa's to block the TF-FVIIa complex's procoagulant activity.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Range:
- 31.25-2000 pg/mL
- Reactivities:
- Mouse
- Sensitivity:
- 18.75 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:p-mouse_tfpi_(tissue_factor_pathway_inhibitor)_elisa_kit-e_el_m3132
