Anti-Human CD45-FITC/CD3-PE/Cyanine5/CD4-PE/CD8-PE/Elab Fluor[R] 594 Cocktail
Product Sizes
20 tests
£204.00
E-AB-FC0029-20TESTS
100 tests
£404.00
E-AB-FC0029-100TESTS
2 x 100 tests
£597.00
E-AB-FC0029-2X100TESTS
About this Product
- SKU:
- E-AB-FC0029
- Application:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- HI30,OKT-3,SK3,UCHT-4
- Conjugate:
- Cyanine 5, Elab Fluor® 594, FITC, R-PE
- Extra Details:
- This product is a FCM antibody cocktail made up of FITC Anti-Human CD45 Antibody[HI30] (Mouse IgG1, K Kappa), PE/Cyanine5 Anti-Human CD3 Antibody[OKT-3] (Mouse IgG2a, K Kappa), PE Anti-Human CD4 Antibody[SK3] (Mouse IgG1, K Kappa), PE/Elab Fluor® 594 Anti-Human CD8 Antibody[UCHT-4] (Mouse IgG1, K Kappa). CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD3E Epsilon is a 20 kD chain of the CD3/T cell receptor (TCR) complex, which is composed of two CD3E Epsilon, one CD3G Gamma, one CD3D Delta, one CD3Z Zeta (CD247), and a T cell receptor (A Alpha/B Beta or G Gamma/D Delta) heterodimer. It is found on all mature T lymphocytes, NK T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16. CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the A Alpha3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Arrays
- Manufacturer's Data Sheet:8MQ1cBjy
