Anti-Human CD45-FITC/CD3-PE/Cyanine5/CD56/NCAM-PE/CD19-PE/Elab Fluor[R] 594 Cocktail
Product Sizes
20 tests
£221.00
E-AB-FC0028-20TESTS
100 tests
£528.00
E-AB-FC0028-100TESTS
2 x 100 tests
£772.00
E-AB-FC0028-2X100TESTS
About this Product
- SKU:
- E-AB-FC0028
- Application:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- HI30,OKT-3,5.1H11,HI19a
- Conjugate:
- Cyanine 5, Elab Fluor® 594, FITC, R-PE
- Extra Details:
- This product is a FCM antibody cocktail made up of FITC Anti-Human CD45 Antibody[HI30] (Mouse IgG1, K Kappa), PE/Cyanine5 Anti-Human CD3 Antibody[OKT-3] (Mouse IgG2a, K Kappa), PE Anti-Human CD56/NCAM Antibody[5.1H11] (Mouse IgG1, K Kappa), PE/Elab Fluor® 594 Anti-Human CD19 Antibody[HI19a] (Mouse IgG1, K Kappa). CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD3E Epsilon is a 20 kD chain of the CD3/T cell receptor (TCR) complex, which is composed of two CD3E Epsilon, one CD3G Gamma, one CD3D Delta, one CD3Z Zeta (CD247), and a T cell receptor (A Alpha/B Beta or G Gamma/D Delta) heterodimer. It is found on all mature T lymphocytes, NK T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. CD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate. CD19 is a 95 kD type I transmembrane glycoprotein also known as B4. It is a member of the immunoglobulin superfamily expressed on B-cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. CD19 is involved in B cell development, activation, and differentiation. CD19 forms a complex with CD21 (CR2) and CD81 (TAPA-1), and functions as a BCR co-receptor.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Arrays
- Manufacturer's Data Sheet:zUkoQp2W
