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Antibodies

Purified Anti-Human CD74 Antibody[LL1]

Product Sizes
25 ug
£99.00
E-AB-F14210P-25UG
100 ug
£169.00
E-AB-F14210P-100UG
1 mg
£405.00
E-AB-F14210P-1MG
5 mg
£1515.00
E-AB-F14210P-5MG
25 mg
£5832.00
E-AB-F14210P-25MG
50 mg
£10187.00
E-AB-F14210P-50MG
100 mg
£14542.00
E-AB-F14210P-100MG
About this Product
SKU:
E-AB-F14210P
Additional Names:
DHLAG;CD74;HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain (Ii);HLA class II histocompatibility antigen gamma chain
Application:
Flow Cytometry, Western Blot
Buffer:
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
translate.label.attr.clone:
LL1
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-K KappaB activation, and IL-8 production.
Host:
Mouse
Immunogen:
CD74|Recombinant Human CD74 protein
Isotype:
IgG1, kappa
Purity:
>98%
Purification:
protein a/g purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
  • Manufacturer's Data Sheet:OtHGZ9
HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-2 gene were stained with 0.2 ug Purified Anti-Human IL-2 Antibody[MQ1-17H12] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-2 gene were stained with 0.2 ug AF/LE Purified Anti-Human IL-2 Antibody[MQ1-17H12] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse IL-2 gene were stained with 0.2 ug AF/LE Purified Anti-Mouse IL-2 Antibody[JES6-5H4] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor®647-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-2 gene were stained with 0.2 ug Purified Anti-Human IL-2 Antibody[MQ1-17H12] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse IL-2 gene were stained with 0.2 ug Purified Anti-Mouse IL-2 Antibody[JES6-5H4] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor®647-conjugated Goat Anti-Rat IgG Secondary Antibody.