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Antibodies

Purified Anti-Mouse CD172a Antibody[P84], Functional Grade

Product Sizes
100 ug
£89.00
E-AB-F12860-100UG
1 mg
£171.00
E-AB-F12860-1MG
5 mg
£490.00
E-AB-F12860-5MG
25 mg
£1515.00
E-AB-F12860-25MG
50 mg
£2247.00
E-AB-F12860-50MG
100 mg
£3211.00
E-AB-F12860-100MG
About this Product
SKU:
E-AB-F12860
Additional Names:
Myd,SHPS,Ptpns,Bit,Myd1,Ptpns1,Shps1,Sirp,Sirpa, SIRP&amp,beta-1-1,SIRP&amp,alpha,SIRP&amp,beta,AI835480,CD172a,P84,SHP-1,SHPS-1
Application:
Block/Inhibit/Neutralise, Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
P84
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
Host:
Rat
Immunogen:
Recombinant Mouse CD172a protein
Isotype:
IgG1, kappa
Purity:
>98%
Purification:
protein a/g purified
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
C57/BL6 Mouse bone marrow were stained with 0.2 ug Purified Anti-Mouse CD172a Antibody[P84], Functional Grade (Right) and 0.2 ug Rat IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
Human peripheral blood lymphocytes cell were stained with 0.2 ug AF/LE Purified Anti-Human CD25 Antibody[7G7B6] (Right) and 0.2 ug Mouse IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD4 PE-conjugated Monoclonal Antibody.
K562 were stained with 0.2 ug Purified Anti-Human CD49e Antibody[IIA1] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood granulocytes cell were stained with 0.2 ug Purified Anti-Human CD32 Antibody[AT10] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood Granulocyte cell were stained with 0.2 ug Purified Anti-Human CD87 Antibody[10E1] (Right) and 0.2 ug Rat IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Ret IgG Secondary Antibody.