Purified Anti-Human IL-2 Antibody[MQ1-17H12]
Product Sizes
25 ug
£66.00
E-AB-F1200A-25UG
100 ug
£89.00
E-AB-F1200A-100UG
1 mg
£165.00
E-AB-F1200A-1MG
5 mg
£467.00
E-AB-F1200A-5MG
25 mg
£1438.00
E-AB-F1200A-25MG
50 mg
£2132.00
E-AB-F1200A-50MG
100 mg
£2980.00
E-AB-F1200A-100MG
About this Product
- SKU:
- E-AB-F1200A
- Additional Names:
- IL2;IL-2;TCGF;lymphokine;Aldesleukin;IL-2lymphokine;interleukin-2;Proleukin;interleukin 2;involved in regulation of T-cell clonal expansion;T cell growth factor;T-cell growth factor;IL 2;IL2;Interleukin 2;interleukin2;Involved in regulation of T cell clonal expansion;Lymphokine;POIL2;T Cell Growth Factor;TCGF
- Application:
- Flow Cytometry
- Buffer:
- Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
- translate.label.attr.clone:
- MQ1-17H12
- Clonality:
- Monoclonal
- Concentration:
- >= 1 mg/ml
- Extra Details:
- Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma D Delta T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% aa sequence identity with Mouse and Rat IL-2, respectively. Human and Mouse IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to prolifeRate and induces IL-2 and IL-2 R alpha synthesis. It contributes to T cell homeostasis by promoting the Fas-induced death of naive CD4+ T cells but not activated CD4+ memory lymphocytes. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity.
- Host:
- Rat
- Immunogen:
- IL-2|Recombinant Human IL-2 protein
- Isotype:
- IgG2a, kappa
- Purity:
- >98%
- Purification:
- protein a/g purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:48CG08
