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Antibodies

Purified Anti-Mouse IL-10 Antibody[JES5-16E3]

Product Sizes
25 ug
£99.00
E-AB-F1197A-25UG
100 ug
£169.00
E-AB-F1197A-100UG
1 mg
£405.00
E-AB-F1197A-1MG
5 mg
£1515.00
E-AB-F1197A-5MG
25 mg
£5832.00
E-AB-F1197A-25MG
50 mg
£10187.00
E-AB-F1197A-50MG
100 mg
£14542.00
E-AB-F1197A-100MG
About this Product
SKU:
E-AB-F1197A
Additional Names:
Interleukin;IL-;CSIF;If2a;Il-10;IL10A;TGIF;Interleukin-10;IL10;Cytokine synthesis inhibitory factor;N/A;CSIF;If2a;Il-10
Application:
Flow Cytometry
Buffer:
PBS, pH 7.2. Contains 0.05% proclin 300.
translate.label.attr.clone:
JES5-16E3
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation.
Host:
Rat
Immunogen:
IL-10|Recombinant Mouse IL-10 protein
Isotype:
IgG2b, kappa
Purity:
>98%
Purification:
protein a/g purified
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse MHC II (I-A/I-E) Antibody[M5/114](Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control(Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
Jurkat were activated for 4 hour with MIX, then stained with 0.2 ug Purified Anti-Human CD83 Antibody[HB15e] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug AF/LE Purified Anti-Mouse CD86 Antibody[GL-1] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by PE-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse MHC II (I-A/I-E) Antibody[M5/114](Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control(Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse CD11c Antibody[N418] (Right) and 0.2 ug Armenian Hamster IgG, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti- Armenian Hamster IgG Secondary Antibody, then anti-Mouse MHC II FITC-conjugated Monoclonal Antibody.