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Antibodies

Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3], Functional Grade

Product Sizes
100 ug
£89.00
E-AB-F11330-100UG
1 mg
£171.00
E-AB-F11330-1MG
5 mg
£490.00
E-AB-F11330-5MG
25 mg
£1515.00
E-AB-F11330-25MG
50 mg
£2247.00
E-AB-F11330-50MG
100 mg
£3211.00
E-AB-F11330-100MG
About this Product
SKU:
E-AB-F11330
Additional Names:
B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1,B7 homolog 1,B7-H,B7-H1,Programmed cell death ligand 1
Application:
Block/Inhibit/Neutralise, Cell-based/Functional Assay, Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
29E.2A3
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-G Gamma production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
Host:
Mouse
Immunogen:
Recombinant Human PD-L1 protein
Isotype:
IgG2b, kappa
Purity:
>98%
Purification:
protein a/g purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Human peripheral blood lymphocytes were activated for 3 days with PHA, then stained with 0.2 ug Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3], Functional Grade (Right) and 0.2 ug Mouse IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD3 PE-conjugated Monoclonal Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD62L Antibody[DREG56] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD29 Antibody[TS2/16.2.1] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by APC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug AF/LE Purified Anti-Human CD62L Antibody[DREG56] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD45RA Antibody[HI100] (Right) and 0.2 ug Mouse IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.