AF/LE Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3]
Product Sizes
50 ug
£220.00
E-AB-F11330-50UG
500 ug
£541.00
E-AB-F11330-500UG
1 mg
£755.00
E-AB-F11330-1MG
About this Product
- SKU:
- E-AB-F11330
- Additional Names:
- B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
- Application:
- Block/Inhibit/Neutralise, Cell-based/Functional Assay, Flow Cytometry
- Buffer:
- 0.2 uM PBS
- Clone:
- 29E.2A3
- Clonality:
- Monoclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-G Gamma production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
- Host:
- Mouse
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-af_le_purified_anti_human_cd274_pd_l1_antibody_29e.2a3_e_ab_f11330-176606.html