AF/LE Purified Anti-Human CD279/PD-1 Antibody[J116]
Product Sizes
50 ug
£220.00
E-AB-F11290-50UG
500 ug
£541.00
E-AB-F11290-500UG
1 mg
£755.00
E-AB-F11290-1MG
About this Product
- SKU:
- E-AB-F11290
- Additional Names:
- PD-1, Programmed Death-1
- Application:
- Block/Inhibit/Neutralise, Flow Cytometry
- Buffer:
- 0.2 uM PBS
- Clone:
- J116
- Clonality:
- Monoclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
- Host:
- Mouse
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-af_le_purified_anti_human_cd279_pd_1_antibody_j116_e_ab_f11290-178513.html